Cell and developmental biology of

early oogenesis

RESEARCH

From the stem cell to the follicle:

novel cellular mechanisms of oocyte differentiation by a centrosome organizing center

PROJECTS

Mechanisms of the centrosome organizing center and the coordination of cellular compartments in oocyte symmetry breaking

Upstream regulation of the centrosome organizing center by the mitotic program

Oocyte polarization utilizes prion-like mechanisms

Ciliary functions in early oogenesis

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TEAM

Talented students, postdocs and staff are wanted!

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Our recent discovery of a previously unknown organelle in developing egg and sperm cells

Document

Read more in
Mytlis, Kumar et al., Science (2022)
Here:

ABOUT US

Our lab investigates cellular mechanisms of early oocyte differentiation, from the stem cell to the follicle.

We have discovered a novel cellular organizer that integrates multiple cellular processes such as mitosis, meiosis, cell polarity, prion-like mechanisms, mechanical regulation and ciliary functions in the oocyte. Its investigation allows us to study how these programs are coordinated by the cell on a single platform of early oogenesis.

We use zebrafish as our model and utilize methods of advanced genetics and quantitative microscopy.